Positioning Vascularized Composite Allotransplantation within the Spectrum of Transplantation
Technical Report,15 Sep 2014,14 Sep 2015
Christine M. Kleinert Institute Louisville United States
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The purpose of this project is to enable more patients to access VCA transplantation. The work in Louisville will focus on using non-invasive imaging techniques that can be used to monitor vessels and nerves in VCA recipients Aim 6. The goal is to identify changes while there is still time to intervene. Studies are initiated using infrared imaging of ICG dye to study blood perfusion and lymphatic drainage in our hand transplant patients. We are extending our studies of vessel wall thickness using very high resolution ultrasound, and including non-invasive studies of nerve anatomy. In Aim 7 we established a rodent model to study VCA vasculopathy, both with respect to imaging modalities and what factors initiate or exacerbate graft vasculopathy. Initial IR-ICG imaging studies of graft perfusion correlate well with acute graft rejection in our animals. Finally in Aim 8 we will develop standardization of protocols and clinical monitoring and treatment for VCA targeting vascular health.