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Systematic Characterization of the Molecular Mechanisms That Regulate and Mediate Alternative Lengthening of Telomeres in Breast Carcinoma

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Technical Report,15 Mar 2012,14 Mar 2015

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Dana-Farber Cancer Institute Boston United States

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Alternative lengthening of telomeres ALT is a mechanism utilized by several cancer types to maintain telomeres. The aim of this project is to characterize the mechanisms that mediate and regulate ALT activity in breast cancer, by utilizing proteomic and genomic approaches to describe and perturb ALT cells. Gaining this knowledge on ALT activity can promote the development of novel treatment for ALT breast tumors, and patients with telomerase inhibitor resistant tumors, while having minimal non-desired effects on the normal cell population that typically has no ALT activity. Here, I report on my progress in profiling and analyzing a collection of ALT and non-ALT cell-lines in order to define an ALT expression signature, which highlights potential mechanism and vulnerabilities of ALT cells. In addition, I report on the profiling of transcriptional changes that occur upon suppression of ATRX.

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