Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury
Technical Report,15 Aug 2012,14 Aug 2015
University of Tennessee Health Science Center Memphis United States
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In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.