Accession Number:

AD1007135

Title:

Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury

Descriptive Note:

Technical Report,15 Aug 2012,14 Aug 2015

Corporate Author:

University of Tennessee Health Science Center Memphis United States

Personal Author(s):

Report Date:

2015-11-01

Pagination or Media Count:

30.0

Abstract:

In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE