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DARPA Antibody Technology Program Standardized Test Bed for Antibody Characterization: Characterization of an MS2 ScFv Antibody

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Technical Report,01 Oct 2010,01 Sep 2012

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Army Edgewood Chemical Biological Center Aperdeen Proving Ground

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The selection of antibodies for inclusion in a final assay format has primarily relied on an antibodys performance in an enzyme-linked immunosorbent assay ELISA, with little regard for quantification of the full spectrum of variables affecting antibodyantigen interactions. The Joint Product Management Office for Biosurveillance JPMO BSV Critical Reagents Program has recently instituted a quality program for standardization of test methods to support more comprehensive characterization and comparison of the physical and functional properties of antibody reagents within its repository. The development and standardization of antibody testing provides JPMO BSV with an invaluable platform for the provision of consistent, high-quality assays and reagents for current biodetection platforms as well as the development and validation of future systems. This platform will be used to characterize the MS2 recombinant antibody produced at U.S. Army Edgewood Chemical Biological Center for the Defense Advanced Research Projects Agency DARPA Antibody Technology Program ATP.

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