Contribution of Interstitial Deletion of 21q22.2-3 per se to Prostate Cancer Progression in Tumors Harboring TMPRSS2-ERG Translocations
Technical Report,15 Sep 2014,14 Sep 2015
Tulane University New Orleans United States
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TMPRSS2-ERG gene fusions are present in close to 50 of human prostate cancers. Approximately half of the fusions are generated through an interstitial deletion between these two genes, and the other half through an interchromosomal insertion. The deletion class is in general more aggressive than the insertion class. The purpose of this study is to understand the mechanism underlying the aggressive phenotype of the deletion class of TMPRSS2-ERG-positive prostate cancers. We identified two potential tumor suppressor genes in this deleted region. The loss of these two genes may work together withTMPRSS2-ERG to drive prostate cancer progression. Understanding the function of the interstitial deletion may provide markers to distinguish aggressive from indolent disease and will facilitate rational design of therapeutic approaches to improve the treatment of this appreciable group of patients.