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Molecular Characterization of Indolent Prostate Cancer

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Technical Report,15 Sep 2014,14 Sep 2015

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Johns Hopkins University Baltimore United States

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Indolent prostate cancers that pose very low risk to aged men occur frequently and may be detected at biopsy, leading to the contemporary problem of prostate cancer over-diagnosis and over-treatment. The objective of the project is to define and characterize indolent prostate cancer using genomic approaches in the clinically relevant context of a cohort meeting the entry criteria for active surveillance. During this funding period, we focused on analysis of clinical specimens suitable for RNA sequencing, and identified a finalized set of specimens taking into consideration of the age effect. We have requested a no-cost extension for an additional 12 months to allow a final analysis to be performed and reported. These progresses represent necessary interim processes that will position us for the proposed studies designed to maximize the potential impact in the context of technical advances in the field.

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