Synthetic Biological Engineering of Photosynthesis
Technical Report,15 Jun 2009,14 Jun 2014
Harvard Medical School Boston United States
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The overall goal of the grant is to create a synthetic biology platform based on solar energy that can be used on a local level to generate bulk amounts of chemical commodities. The specific aims of the original proposal are to construct a photosynthetic cynaobacterium that 1produces hydrogen by directed electron flow from the photosynthetic machinery and 2 produces short alkyl chains by channeling electrons from photosynthesis into artificial metabolic pathways. During the course of the granting period, we also made significant progress on understanding the compartmentalization of carbon fixation and flux in relationship to photosynthesis and obtained increases in photosynthetic activity that have broad implications for production of commodities on demand.