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Dissecting the Roles of Brain Injury and Combat-Related Stress in Post-Traumatic Headache

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Technical Report,30 Sep 2014,29 Sep 2015

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University of Utah Salt Lake City United States

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Military traumatic brain injury TBI typically involves blast exposure, and typically occurs in an environment of extreme stress. One of the most common and debilitating consequences of TBI is post-traumatic headache PTH. Because both TBI and stress could contribute to PTH, we examine them together and separately, attempting to understand the mechanisms by which they generate PTH, and to develop new treatments for the disorder tailored to both injury and stress mechanisms.In the first year of this project, a significant portion our time has been spent in the ACURO approval process. We obtained ACURO approval in the middle of the third quarter of the calendar year. Prior to ACURO approval on an unfunded basis weset up the blast apparatus in our lab and began validation work in this new setting. Since ACURO approval, we have continued validation work for all of the modalities we will need in the project blast, sensory physiology, and behavior and begun experiments.

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