Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model
Technical Report,30 Sep 2013,29 Sep 2015
Henry M Jackson Foundation for the Advancement of Military Medicine Bethesda United States
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This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The results showed that scraping the inner surface of the induced membrane provided a highly desirable environment that promoted more bone regeneration by providing exposure of the autograft placed in the defect site to fresh blood and competing non-osteogenic cells.