Accession Number:

AD1006379

Title:

Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model

Descriptive Note:

Technical Report,30 Sep 2013,29 Sep 2015

Corporate Author:

Henry M Jackson Foundation for the Advancement of Military Medicine Bethesda United States

Personal Author(s):

• Forsberg,Jonathan

Report Date:

2015-12-01

Pagination or Media Count:

18.0

Abstract:

This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The results showed that scraping the inner surface of the induced membrane provided a highly desirable environment that promoted more bone regeneration by providing exposure of the autograft placed in the defect site to fresh blood and competing non-osteogenic cells.

Descriptors:

• military medicine
• bone fractures
• tibia
• surgical transplantation
• connective tissue

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE