Pathology Report for Intraperitoneal Sodium Dichromate Exposure in Rats, Protocol No. 15-002-3
Technical Report,01 Aug 2015,31 Dec 2015
Army Public Health Center (Provisiona) Aberdeen Proving Ground United States
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Hexavalent chromium is an oxidizing agent and known carcinogen that is extensively used. It affects the respiratory tract, gastrointestinal tract, liver, kidneys and immune system. To protect Soldier health, additional information on the mechanism of toxicity were sought. Groups of rats were given a single IP injection of saline vehicle or increasing doses of Na2Cr2O7, euthanized 1, 3, 7 or 14 days later, and tissues examined. Liver and kidney exhibited direct injury to the capsule and underlying parenchyma. Lesions were present 1 day after injection and persisted. This may be the first report in rats that suggests persistent injury after 1 exposure underscoring the need for detection capability to prevent Soldier exposure.