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A Molecular Framework for Understanding DCIS

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Technical Report,30 Sep 2014,29 Sep 2015

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The Chancellor, Masters and Scholars of the University of Cambridge Cambridge United Kingdom

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This project centers on creating a molecular framework of DCIS ductal carcinoma in situ. DCIS is considered to be the precursor to Invasive Ductal Carcinoma IDC, the most common form of breast cancer. IDC accounts for 80 of all breast cancers, predominantly affecting women aged 55 and older however, at least a third of women with IDC are diagnosed before they reach 55. Not all patients with DCIS will develop IDC however, we are looking for ways to better predict those patients that need life-saving treatment, and separate these from those patients who are less at risk.So far we have 2060 lesions dissected from freshly frozen biopsies, these have been annotated by our pathologist and prepared to be taken on for sequencing. The tissue includes DCIS, IDC, stroma adjacent to DCISIDC and normal tissue. We have initiated the RNA sequencing from these samples and also the DNA sequencing.

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