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A Label-Free and Chemical-Selective Microendoscope to Enhance Prostate Cancer Surgical Outcomes

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Technical Report,30 Sep 2014,29 Sep 2015

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Methodist Hospital Research Institute Houston United States

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Direct visualization of cavernous nerves CNs and prostate surgical margins can improve nerve preservation and postoperative potency of radical prostatectomy. Coherent Anti-Stokes Raman scattering CARS is a label-free imaging technique which can differentiate prostate cancer tissues and cavernous nerves CNs without the use of any labeling agents. However, one major obstacle for intraoperative application of CARS is the bulky size of the original CARS system which was built on free space optics. In previous calendar years, we have successfully refined our original bulky CARS system into a compact fiber-based microendoscope device and finished the development of a miniaturized fiber probe. Wehave also tested the feasibility of using TRAMP mice for prostate surgical margin imaging. The next step will be in vivo imaging and algorithm development with the all-fiber microendoscope system. This work presents a significant milestone in CARS endoscopy development using micro optics to greatly reduce the size of CARS endoscopy while keeping high imaging definition quality.

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