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Transforming Research and Clinical Knowledge in Traumatic Brain Injury

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Technical Report,26 Sep 2014,25 Sep 2015

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University of California, San Francisco San Francisco United States

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Using the TRACK-TBI Transforming Research and Clinical Knowledge in TBI dataset we have created an Information Commons that integrates clinical, imaging, proteomic, genomic, and outcome biomarkers based upon the domains of the TBI Common Data Elements. The comprehensive TBI-CDE outcome measures allow for analyses of biomarker associations with a variety of measures. Available prognostic models have been evaluated against new prognostic models for TBI and found to be unsatisfactory using a multivariate approach that goes beyond the crude definitions of Mild, Moderate and Severe TBI. The latest neuroimaging methods including Quantitative CT, DTI, and resting-state functional MRI are surpassing other methods for predicting TBI patient outcomes. In emergency settings where high resolution neuroimaging is not available, rapid measurement of proteomic markers is appearing to be a valuable adjunct to current screening practices for ruling out TBI. Most importantly improving the collection of biomarkers in TBI patients will be vital to the design of future clinical trials.

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