Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer
Technical Report,15 Sep 2011,14 Sep 2015
UNIVERSITY OF COLORADO DENVER United States
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Colorectal cancer CRC represents a major health burden, and is the third leading cause of cancer deaths in the U.S. In the past decade, the median survival among patients with metastatic CRC has significantly improved, primarily due the development of active chemotherapeutic regimens that include biological agents. However, despite this success, patients soon run out of therapeutic options and receive salvage therapy that results in only a few weeks of disease stability. We have proposed to employ a team science, systems biology based approach to rapidly identify novel anti-cancer agents and individualize therapeutic strategies in preclinical CRC models. In this Final Report, we will present the tasks and key accomplishments achieved within the funding of this project. We have published two papers, and are in the preparation of another three manuscripts from the results generated from this project. In summary, we have accomplished all the tasks in this proposal.