DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
AD1006257
Title:
Monoamine Oxidase A: A Novel Target for Progression and Metastasis of Prostate Cancer
Descriptive Note:
Technical Report,30 Sep 2012,29 Sep 2015
Corporate Author:
University of Southern California Los Angeles United States
Report Date:
2015-12-01
Pagination or Media Count:
105.0
Abstract:
The purpose of this project is to investigate the key roles of the monoamine oxidase A MAO A enzyme in the progression and metastasis of prostate cancer PCa. During this funding period, we delineated the functional and mechanistic roles of MAO A in promoting tumor metastasis, determined MAO A functions in PCa by defining its roles in reactive oxygen species production and augmentation of HIF1-mediated signaling, and developed a MHI clorgyline, a novel pharmacological inhibitor of MAO A for targeted therapy and noninvasive imaging of PCa. Throughout the Year 3, we investigated the effect of hypoxia on MAO A and found that hypoxia induces MAO A expression and activity. We assessed the tumor-targeting properties of NIR-clorgyline for PCa in vivo and demonstrated its tumor-specificity in mouse xenograft model through NIR near infrared imaging. We generated MAO APten double KO mice and showed that deletion of MAO A delays PCa development and facilitates an immunostimulatory environment in the Pten KO mouse model of prostate adenocarcinoma.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
