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Advanced MRI in Acute Military TBI

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Technical Report,01 Sep 2010,31 Aug 2015

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Washington University ST. Louis United States

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The objective of the project is to test two advanced MRI methods, DTI and resting-state fMRI correlation analysis, in military TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. An additional objective is to test the interaction of candidate genetic vulnerability factors with patterns of injury. The hypothesis was that these combined methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis is that traumatic axonal injury, interacting with genetic vulnerability factors, is a principal cause of impaired brain function following blast-related and non-blast-related TBI. The study was a prospective longitudinal study with subject enrollment and initial evaluation at Landstuhl Regional Medical Center in Landstuhl Germany and at 2 sites in Afghanistan. Follow-up evaluations are performed at Washington University in St Louis. Enrollment was closed June 1, 2013. Follow-up was completed on November 17, 2013. 255 subjects were enrolled at LRMC and 230 subjects were enrolled in Afghanistan. 182 subjects enrolled at LRMC and 73 subjects enrolled in Afghanistan have completed follow-up evaluations. There have been no adverse events. We have published 4 papers and have 1 final manuscript under review.

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