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Detection of Brain Reorganization in Pediatric Multiple Sclerosis Using Functional MRI

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Technical Report,30 Sep 2014,29 Sep 2015

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Children's Hospital Corporation Boston United States

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Due to slower than expected study recruitment and imaging of patient cohort, progress over the 2015 funding period was delayed. This resulted in a 12-month extension over which time the main study conclusions are planned to be completed. Despite the incomplete cohort, we performed preliminary study using a smaller cohort and made significant findings which support the main objectives of the planned research. Significant findings include 1 detection of brain organization in a cohort of 24 pediatric onset multiple sclerosis patients POMS and 25 healthy controls demonstrated congruency between fMRI mappings and patient performance 2 testing of the fMRI methods we developed for use in POMS patients was carried out in a group of 42 presurgical pediatric patients at our institution, demonstrating reliable fMRI mappings of language and motor systems using our methods in the pediatric brain. Item 1 we found that 12 of 12 POMS patients presenting with mild to severe deficits as measured by neuropsychological exam also demonstrated abnormal brain function as measured by our fMRI methods. These preliminary findings support our project hypothesis that POMS patients who suffer from impairment will also demonstrate abnormal fMRI mappings. Item 2 the information provided to surgeons by our fMRI methods allowed the potential to spare pediatric patients post-operative impairment in any language or motor functions that were located near a planned surgical site.

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