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Comprehensive Evaluation of Altered Systemic Metabolism and Pancreatic Cancer Risk

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Technical Report,30 Sep 2014,29 Sep 2015

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Dana-Farber Cancer Institute Boston United States

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An increased risk of pancreatic cancer and reduced survival is seen among patients with altered systemic metabolism, including obesity, hyperglycemia, and hyperinsulinemia. However, the mechanisms by which altered metabolism may promote pancreatic cancer development and growth remain to be identified.The primary purpose of the funded research is to understand the metabolic alterations that promote development of early pancreatic cancers and impact their proliferation. To explore altered metabolism is patients with pancreatic cancer, we are conducting studies in participants from four large prospective cohorts,where individuals provide extensive data on metabolic phenotypes, such as obesity and diabetes, and banked plasma samples for interrogation. The potential impact of understanding the mechanisms underlying early pancreatic cancer growth is substantial, with an improved ability to a diagnose pancreatic cancerat an earlier stage when cure is possible, b formulate preventative recommendations based on an individuals metabolic phenotype, and c identify novel treatment strategies that disrupt pancreatic tumor metabolism.

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