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Role of Klotho in Osteoporosis and Renal Osteodystrophy

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Technical Report,30 Sep 2014,29 Sep 2015

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Harvard University Boston United States

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The most significant findings from the last period are the following. 1 We are the first to show that Klotho is expressed in proximal tubules and that in vivo deletion of Klotho from proximal tubules leads to reduced urinary phosphate wasting AIM 2. Three mouse models were established to confirm our findings. It seems, however, that there is an interrelationship between proximal and distal tubules since deletion of Klotho from either target tissue leads only to a mild phenotype, so compensatory mechanisms are suggested. 2 In AIM3 we found that Klotho expression in bone forming cells is required to induce FGF23 transcription upon renal failure. Such findings can ultimately lead to therapeutic interventions to block the increase in FGF23 production during renal failure. Here two mouse models resulted in similar results, so we are very confident about our results.

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