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Functional Analysis of Somatic Mutations in Lung Cancer

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Technical Report,01 Aug 2012,31 Jul 2015

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Dana-Farber Cancer Institute Boston United States

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We have conducted functional investigations of somatic mutations in lung cancer, focusing on genesallelic variants individually and also using high throughput combinatorial approaches. We have gained insights into the impact of somatic mutations inRBM10, MAP2K1, ERBB2, EGFR and a host of other oncogenes or tumor suppressor proteins, on the initiation and maintenance of lung cancer. Notably, we have revealed for the first time the mechanism by which amplifications in an enhancer region a novel super-enhancer, upstream of the MYC promoter, drives carcinogenesis. During the course of this project, we have also developed novel in vitro and in vivo experimental and analytical approaches, including genome editing methods, to augment our own research capabilities and that of the broader scientific community. The significance of our findings lies in the fact that we have now gained valuable insights into the molecular mechanisms by which somatic mutations in lung cancerthat were previously detected by large-scale, genomics approaches and were of unknown significanceincite tumorigenesis. The next step would be to translate this knowledge to devising more effective and tumor-specific targeted therapies, to benefit lung cancer patients.

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