Functional Analysis of Frequent Lung Cancer Amplicons Under Current Genome Annotation
Technical Report,30 Sep 2014,29 Sep 2015
Eastern Virginia Medical School Norfolk
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A significant number of lung cancer amplicons were established between mid and late 2000s using the array-based genomic tools. Thus, the known gene compositions of many MRAs are devoid of the genes only recently discovered. Exemplary groups of such genes include many non-protein-coding genes like long non-coding RNAs and microRNAs miRNAs. In study, we examined the PVT1-encoded miRNAs embedded in one of the most recurrent amplicons at 8q24. The results indicate that these miRNAs are not likely functionally relevant to lung tumorigenesis. The implication is that future studies of the 8q24 amplicon should concentrate on characterizing the PVT1 RNA transcript.