Accession Number:

AD1005269

Title:

Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

Descriptive Note:

Technical Report,15 Aug 2013,14 Aug 2015

Corporate Author:

University of Copenhagen Copenhagen Denmark

Personal Author(s):

Report Date:

2015-11-01

Pagination or Media Count:

59.0

Abstract:

We have successfully produced recombinant malaria derived VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSAinterferes with key functions of the cancer cell like growth, migration and invasion. In vivo models demonstrate that conjugation of a toxin to VAR2CSA followed by IV administration to metastatic breast cancer bearing mice completely cures the animals.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE