Tinnitus Multimodal Imaging
Technical Report,30 Sep 2014,29 Sep 2015
University of California, San Francisco San Francisco United States
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Tinnitus is a common auditory perceptual disorder whose neural substrates are under intense debate. This project takes a multimodal imaging approach to better understand whole brain network connectivity abnormalities. Resting-state fMRI reveals increased corticostriatal connectivity isolated to area LC of the caudate, which is positioned at the junction of the head and body of the nucleus. Other patterns of increased connectivity include caudate head with cingulate gyrus of the default mode network. Those findings provide further evidence to support the striatal gating model of tinnitus, where dysfunctionally permissive area LC enables auditory phantoms to reach perceptual awareness. Magnetoencephalographic resting-state functional connectivity imaging MEGI in tinnitus subjects in the alpha-band shows increased connectivity in bilateral middle frontal gyrus MFG, left postcentral gyrus, and left inferior parietal lobule. 7T MR spectroscopic imaging MRSI methods have successful capture of distinct GABA signals in the caudate nucleus and auditory cortices reliably.