Demyelination as a Target for Cell-Based Therapy of Chronic Blast-Induced Traumatic Brain Injury
Technical Report,30 Sep 2014,29 Sep 2015
Johns Hopkins University Baltimore United States
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The burden of traumatic brain injury TBI is expressed in the disabling behavioral and cognitive abnormalities noted in significant number of combat veterans. These clinical phenotypes suggest impairment in distributed cerebral functions dependent on the integrity of white matter WM tracts. In this proposal we explore mechanisms of mild blast trauma-associated demyelination, with the goal of testing a therapeutic strategy to enhance remyelination using human glial restricted progenitors hGRPs Q Therapeutics Inc..