A Novel Mechanism for the Pathogenesis of Nonmelanoma Skin Cancer Resulting from Early Exposure to Ultraviolet Light
Technical Report,12 Sep 2012,31 Aug 2015
University of Minnesota, Twin Cities Minneapolis United States
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Skin egress, entering the circulation, and traveling throughout the body may be a characteristic of skin stem cells. We have made several novel findings in this regard 1 murine epidermal keratinocytes migrate preferentially in vitro to bone marrow cells, 2 keratinocytes migrate towards SDF1 alpha and HMGB1 baits over control attractants. 3 CD184 is expressed on approximately 27 percent of CD49fCD34 hair follicle stem cells, and 4 CD49fKeratin 14 cells in increase in blood and bone marrow following solar UV treatment. 5 Skin grafting studies demonstrated that grafted cells appear in bone marrow. 6 DMBATPA studies showed that keratinocytes migrated from the epidermis during the early stages of skin tumor promotion. 7 We demonstrated using our K14mTmG transgenic mice that a low but significant number of K14-expressing cells are found in the bone marrow. These findings support our hypothesis that 1 skin egress may be a characteristic of skin stem cells in response to damage, and 2 bone marrow may be a long-lived reservoir of sunlight initiated stem cells that can repopulate the skin even years later following damage to the skin.