Low-Intensity Vibration as a Treatment for Traumatic Muscle Injury
Technical Report,01 Aug 2014,31 Jul 2015
University of Illinois Chicago United States
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Traumatic musculoskeletal injuries are among the most common injuries experienced during military combat. Poor healing of traumatic muscle injuries is associated with impaired muscle function, joint stiffness and loss of mobility. Our long-term goal is to develop a device and treatment protocol that provide a safe, inexpensive, and easy to apply treatment that will help to restore normal muscle and joint function to injured military personnel. In this report, we provide preliminary data indicating a trend towards improved healing with LIV. We observed a trend towards a larger fiber area and increased angiogenesis in muscles from LIV-treated mice vs. controls. We have initiated additional experiments to follow up on these findings. Furthermore, initial in vitro studies in macrophages Mp demonstrated that these cells are responsive to the LIV signals and that LIV downregulates the expression of pro-inflammatory markers and upregulates the expression of pro-healing markers in Mp. Findings from continued work on this project will provide insight into the potential for LIV as a non-invasive and simple treatment for improving muscle healing, thereby reducing joint stiffness and increasing mobility of polytrauma patients.