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Mammographic Breast Density in a Cohort of Medically Underserved Women

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Technical Report,20 Sep 2010,19 Sep 2015

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Meharry Medical College Nashville United States

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The purpose of this HBCUMI Partnership Training Award was to train Meharry Medical College MMC faculty to conduct independent breast cancer research by collaborating with faculty from Vanderbilt University Medical Center VUMC. Year 1 was a training year and during Years 2 through 4 a case-control study of obesity, insulin resistance and mammographic breast density was conducted. A no cost extension through 9 months of Year 5 was used to conduct final analyses, and disseminate results to researchers and participants. Specific aims included 1 to assess mammographic breast density through digital mammograms for a sample of women we will also assess mammographic breast density through film mammograms to determine the diagnostic accuracy of digital versus film mammogram, 2 to obtain information on breast cancer risk factors including health literacy, and to collect anthropometric measurements and fasting blood, 3 to assay blood for select hormones and growth factors, 4 to perform statistical analyses to determine the associations between obesity and insulin resistance and mammographic breast density, and 5 to evaluate patients ability to understand their mammogram findings as they are explained by their medical provider. Subject recruitment data collection through questionnaires, body measurements and digital mammograms blood collection, processing and assaying for hormones, growth factors and adipokines quality assurance, interim and final analyses of data and dissemination of results as a published manuscript and as a newsletter was completed on 476 women. MMC investigators attendedpresented at conferences and, in collaboration with VUMC investigators, published three manuscripts and produced a lay version of results for participants.

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