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Epilepsy and the Wnt Signaling Pathway

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Technical Report,01 Jun 2014,31 May 2015

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University of Colorado Aurora United States

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Epileptogenesis is a gradual process by which normal brain transforms into one that sustains seizures. It is instigated by an inciting event e.g. prolonged seizure called status epilepticus SE, head injury, infection or stroke. This is followed by a variable months to years in humans latent period followed by the emergence of spontaneous seizures, with potential for later mood and learning disabilities. While the latent period is a time during which behavioral seizures are not observed, it is a period of tissue and cellular remodeling that sets up the development of chronic seizure activity, or epilepsy. In this grant, we have drawn expertise from other fields to discover new mechanistic insights into epileptogenesis. In the past year, we have expanded our understanding of molecular mechanisms and uncovered new possible insights for therapeutics with a drug combination that we had been developing for breast cancer treatment. Surprisingly, the combination attenuates seizures in two different models of temporal lobe epilepsy.

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