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Noninvasive Label-Free Detection of Micrometastases in the Lymphatics with Ultrasound-Guided Photoacoustic Imaging

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Technical Report,30 Sep 2014,29 Sep 2015

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The University of Texas at Austin Austin United States

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The overall goal of this project is to design, build, and test a clinical ultrasound and photoacoustic imaging system that will detect functional changes associated with lymph node metastasis in breast cancer patients. Our efforts in the first year have focused on preclinical imaging studies of a metastatic mouse model of breast cancer and on clinical system development. While the animal studies are ongoing, we have demonstrated that bioluminescentfluorescent breast cancer cells can reliably metastasize to the regional lymph nodes and optical imaging can be used to guide dissection. We have also successfully integrated a programmable ultrasound machine Verasonics Vantage and tunable pulsed laser Opotek Phocus that will form the basis of the clinical system. We have programmed a graphical user interface that enables real-time acquisition and display of co-registered ultrasound and photoacoustic images. Next steps include finalizing the design of an integrated ultrasound and photoacoustic handheld transducer and obtaining IRB approval.

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