DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
AD1004104
Title:
Environmental Mycobiome Modifiers of Inflammation and Fibrosis in Systemic Sclerosis
Descriptive Note:
Technical Report,20 Aug 2014,19 Aug 2015
Corporate Author:
The Trustees of Dartmouth College Hanover United States
Report Date:
2015-10-01
Pagination or Media Count:
54.0
Abstract:
This project is focused on Systemic Sclerosis SSc, a progressive fibrotic disease characterized by skin fibrosis and damage to internal organs. While a wide range of environmental and biological triggers have been proposed, no definitive etiologic agents have yet been identified. Metagenomic analysis of non-human sequences in SSc RNA-seq data was used to detect microbial sequences in human tissues in an unbiased, quantitative manner. Our studies suggest that disease pathogenesis includes a common environmental fungal trigger, Rhodotorula glutinis, which we hypothesize elicits immune activation in a permissive host genetic background.Skin biopsies have been collected from SSc patients and analyzed by high-throughput sequencing, providing substantial gene expression data as well as detailed information regarding the host microbiome. Data has been compared against that of healthy control samples.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE