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Disruption of Calcium Homeostasis During Exercise as a Mediator of Bone Metabolism

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Technical Report,30 Sep 2014,29 Sep 2015

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University of Colorado Aurora United States

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Experiment 2 is completed, and all batched analysis of samples is finished. Regulatory approvals for EXP3 Pilot andEXP3 were completed in Q34. Completion of 2 successful infusion pilots and 2 successful oral pilots and 1unsuccessful were completed in Q2-4. Approval of the Continuing Review application, which included local approval to proceed with EXP3, was received 8 May 2015. A further amendment to correct recruitment numbers was approved on14 August, 2015. Isotopes for the protocol were ordered delivery occurred 24 August 2015. The isotope has been tested and compounded by the Investigational Pharmacy, and was in use for the most recent pilot infusion experiments. We expect EXP3 to begin in Y4Q1. Wendy Kohrt, PhD, presented preliminary findings from EXP1 and EXP2 at the 2015Annual Meeting of the American College of Sports Medicine and Sarah Wherry, PhD, has submitted the results fromEXP2 for the 2016 Annual Meeting of the American College of Sports Medicine Appendix A.

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