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Hyperpolarized 13C MR Markers of Renal Tumor Aggressiveness

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Technical Report,15 Sep 2012,14 Sep 2015

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University of California, San Francisco San Francisco United States

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RCCs have a wide range of aggressiveness, which is currently difficult to assess noninvasively. There is an unmet clinical need to reliably distinguish RCC from benign renal tumors for optimal triage of therapies. Hyperpolarized HP 13C magnetic resonance MR is a new metabolic imaging approach that is capable of interrogating specific enzymatic pathways in real time. Our aim was to interrogate tumor metabolism in more clinically relevant RCC tumor models by employing patient-derived tumor tissues in conjunction with HP MR. We have shown that in addition to increased lactate production, the clear cell subtype of RCC which makes for the majority of RCCs has a distinct feature of increased lactate efflux which can be used to discern it from benign renal tumors in the ex vivo bioreactor set-up. Additionally we have shown that while patient derived renal tissue slices used in orthotopic mouse model can be established successfully, it is not feasible to conduct hyperpolarized MR experiments due to the limited tumor growth of only the high grade aggressive tumor tissues. Nonetheless in the process, we have used human immortalized RCC cells in the orthotopic mouse model and developed pulse sequences to interrogate increased lactate production as well as efflux using HP13C MR.

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