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microRNA in Prostate Cancer Racial Disparities and Aggressiveness

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Technical Report,30 Sep 2014,29 Sep 2015

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Wayne State University Detroit United States

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Activities during this second year of the project were focused on Tasks 1 and 2 of the statement of work, as planned. Task 1 months 1-30 is to obtain blood and data for 300 new study subjects. In the past year, 59 men were enrolled in the study Task 1.a, for a total of 612 men towards our goal of 800 men. Among enrolled men, blood was collected on 41 men Task 1.b, for a total of 483 blood samples. 29 pre-treatment blood samples were collected Task 1.c, for a total of 115 towards our goal of 150 pre-treatment samples. Questionnaires were completed by 60 men Task 1.d, for a total of 589 completed questionnaires. Our enrollment rate among eligible men continues to be 95. Related to Task 2, we have actively followed all of the enrolled men in the cohort from the previously funded study and from the current protocol who did not have extensive disease at diagnosis for PSA outcomes. Mean follow-up time is currently 57 months. Follow-up of PSA test results through medical records and Caisis database have just been updated, and a linkage with Metropolitan Detroit SEER registry MDCSS will be repeated prior to final analyses.

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