Biomarkers for Autism and for Gastrointestinal and Sleep Problems in Autism
Technical Report,30 Sep 2014,29 Sep 2015
Yale University New Haven United States
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The nighttime and daytime excretions of melatonin sulfate were not significantly different between typically developing TD toddlers and toddlers with autism spectrum disordersASDs. Sleep and gastrointestinalGIproblems were not associated with lower melatonin excretion in TD or ASD toddlers and to a large extent these problems occurred at similar rates in the TD and ASD groups. The expected day-night differences in melatonin sulfate excretion, and in norepinephrine and epinephrine excretion, were seen in both groups. Thus, the lower melatonin production reported for older children with ASD does not appear to occur in toddlers with ASD.