Accession Number:

AD1003913

Title:

Modulation of Pathogenic B Cells through Inhibition of Phosphatidylinositol 3-Kinases

Descriptive Note:

Technical Report,20 Sep 2014,19 Sep 2015

Corporate Author:

SRI International Menlo Park United States

Personal Author(s):

• Stein,Paul L.

Report Date:

2015-10-01

Pagination or Media Count:

12.0

Abstract:

This proposal addresses the FY12 PRMRP topic area on lupus. Lupus is a life threatening disease that primarily affects women. Lupus patients develop antibodies that recognize proteins made by the body. This leads to tissue damage and complexes of the antibodies bound to the proteins can lodge in the kidneys resulting in damage to the filtering capacity of the kidney. The disease is most often managed using drugs that nonspecifically reduce inflammation and suppress the immune system. However that leaves the patient susceptible to other types of infections. Lupus treatment could be improved by specifically targeting the B cells involved in making the self antibodies. This proposal outlines one possible approach that could help solve this problem.

Descriptors:

• AUTOIMMUNE DISEASES

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE