Accession Number:

AD1003263

Title:

EMERGE: Engineered Materials that Create Environments for ReGeneration via Electric Field

Descriptive Note:

Technical Report,24 Sep 2014,23 Sep 2015

Corporate Author:

Johns Hopkins University Applied Physics Laboratory Laurel United States

Personal Author(s):

• Trexler,Morgana
• Caderon-Colon,Xiomara
• Baird,Lance
• Hamilton,Leslie
• Reid,Brian
• Zhao,Min

Report Date:

2015-10-01

Pagination or Media Count:

23.0

Abstract:

The report herein describes progress made in the first year of EMERGE Engineered Materials the Create Environments for ReGeneration via Electric Fields. The objective of the project is to develop a next-generation ocular implant material with biomimetic chemistry and nanotopography with unique drug delivery functionality to 1 provide appropriate biochemical and biophysical cues for enhanced cell migration, differentiation and proliferation and 2 deliver wound electric field enhancing pharmaceuticals for enhanced bioelectronics cues. To this end, we are developing a collagen material with tailored nanotopography with ability to deliver endogenous wound electric field-enhancing molecules that will encourage and accelerate the wound healing process. We monitor wound electrophysiology as a function of time using a vibrating probe.

Descriptors:

• PROSTHETICS

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE