Accession Number:

AD1003211

Title:

Preventing Ototoxic Synergy of Prior Noise Trauma During Aminoglycoside Therapy

Descriptive Note:

Technical Report,01 Dec 2013,30 Nov 2014

Corporate Author:

Oregon Health and Science University Portland United States

Personal Author(s):

• Li,Hongzhe

Report Date:

2014-12-01

Pagination or Media Count:

14.0

Abstract:

Exposure to loud sounds causes temporary or permanent threshold shifts in auditory perception, with reversible or irreversible cellular damage in the cochlea. Noise trauma, or loud sound exposure, is particularly associated with military environments, especially when sustaining blast injuries. These injuries are frequently treated with aminoglycoside antibiotics that have broad-spectrum bactericidal activity for treating or preventing life-threatening infections. However, aminoglycosides are also toxic to the cochlea, leading to hearing loss and further degradation from pre-injury status.

Descriptors:

• TRAUMA
• MILITARY PERSONNEL

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE