Accession Number:

AD1003204

Title:

Early Recognition of Chronic Traumatic Encephalopathy Through FDDNP PET Imaging

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author:

Cleveland Clinic Foundation Cleveland United States

Personal Author(s):

• Bernick,Charles

Report Date:

2015-10-01

Pagination or Media Count:

6.0

Abstract:

The PET biomarker, F-FDDNP 2-1-6-2-F-18fluoroethylmethylamino-2-naphthylethylidene malononitrile FDDNP has shown sensitivity for in vivo detection of tau in addition to -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, andor can predict, decline in cognitive function in those exposed to cumulative head trauma. Enrollment of subjects began in March, 2015, with 19 FDDNP PET images completed. Image quality has been excellent and quantitative analyses will begin when 50 of the subjects are completed. Enrollment has been delayed due to several unavoidable factors, but it is expected that all baseline imaging will be completed by summer, 2016.

Descriptors:

• TRAUMATIC BRAIN INJURIES

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE