Accession Number:

AD1002208

Title:

The Use of Inhibitors of Mechanosensitive Ion Channels as Local Inhibitors of Peripheral Pain

Descriptive Note:

Technical Report,25 Feb 2011,24 Oct 2014

Corporate Author:

Research Foundation of State University of Buffalo Buffalo United States

Personal Author(s):

Report Date:

2015-01-01

Pagination or Media Count:

133.0

Abstract:

Mechanical pain is a major factor in the medical care of soldiers and veterans, whether in acute or chronic injury. Current analgesics, while effective, suffer from a potential for addiction and a variety of negative side effects. We have developed a new class of analgesics based on a peptide that is specific for inhibiting mechanosensitive ion channels. It is non toxic, acts peripherally, may be administered locally or systemically and may be non-addictive. This proposal is to explore the mechanism of action at the cell and molecular level and correlate nerve activation by mechanical stimulation in vitro with pain sensation in animals

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE