Understanding Tumor Dormancy as a Means of Secondary Prevention
Technical Report,15 Sep 2014,14 Sep 2015
Cold Spring Harbor Laboratory Cold Spring Harbor United States
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The purpose of this collaborative project is to establish a molecular definition of the dormant state of a cancer cell. In doing this we hope to understand how this dormancy is broken, ultimately leading to recurrence in a patient that was stably in remission. Once our understanding of this is more complete it is hoped that we can devise strategies for secondary prevention. This funding year we have developed new methods to track dormant cells in vivo, which will also help with RNA extraction and thus transcriptome sequencing. We have also modified our methods to construct mice with markers for tumor niche cells, using the latest technology, and progressed with our work on single chain antibodies, with the intention to use these to identify dormant cells in human biopsies.