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Reinnervation of Paralyzed Muscle by Nerve-Muscle-Endplate Band Grafting

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Technical Report,15 Sep 2014,14 Sep 2015

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Hackensack University Medical Center, Hackensack

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The purpose of this research is to promote the efficacy of our recently developed new surgical technique called nerve-muscle-endplate band grafting NMEG for muscle reinnervation in a rat model. We modified the NMEG procedure by implanting the NMEG pedicle from a donor muscle into the native motor zone NMZ in the experimentally denervated muscle. Three months after surgery, functional recovery of the paralyzed muscles treated with the NMEG-NMZ technique was evaluated by muscle force measurement. The extent of nerve regeneration in the target muscle was assessed using immunohistochemical techniques. Our primary findings showed that NMEG-NMZ technique resulted in better functional recovery 82 of the control as compared with our original NMEG procedure 67. The NMEG-NMZ induced extensive nerve regeneration in the treated muscle. These results suggest that native motor zone in the skeletal muscle is anideal site for muscle reinnervation. NMEG-NMZ technique appears to have the potential for the treatment of muscle paralysis.

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