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Subtyping of Toddlers with ASD Based on Patterns of Social Attention Deficits

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Technical Report,30 Sep 2014,29 Sep 2015

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Yale University New Haven

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The main objective of the proposed project is to elucidate the factors that affect spontaneous dyadic orienting at the earliest stages when ASD can be reliably diagnosed in order to advance our understanding of phenotypic heterogeneity and foster identification of more homogeneous and clinically relevant subgroups within the autism spectrum. Initial major tasks of the research project included regulatory review and approval and preparation of the eye tracking experiment, both completed in Q1Y1. Subject recruitment and enrollment is ongoing. There have not been any other administrative, technical, or logistical issues that impact performance or progress of the study. As of Q4Y2, we have recruited 119 subjects and have enrolled 107 subjects. 43 subjects have ASD, 24 have DD, and 40 are TD. As we have met the study enrollment total for the TD group, in the upcoming period we will focus our efforts exclusively on recruiting into the ASD and DD groups. All enrolled subjects have complete Time 1 subject assessment and data acquisition and 3 have completed Time 2 assessment and data acquisition. Thus far there have been no dropouts or disqualifications. We have made solid progress in implementing the tasks outlined in the SOW. In the upcoming quarter we will begin preliminary analyses of our eye tracking data.

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