Identification and Targeting of Candidate Pre-Existing Lurker Cells that Give Rise to Castration-Resistant Prostate Cancer
Technical Report,30 Sep 2014,29 Sep 2015
University of California, Los Angeles Los Angeles United States
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Castration-resistant prostate cancer CRPC is a lethal disease. We lack standard biomarkers to predict hormonal sensitivity of tumors, and we need new targets for therapy to prevent or treat CRPC. The selection theory predicts that pre-existing androgen-independent prostate cancer cells termed lurker cells contribute to CRPC, as they are not targeted by androgen deprivation therapy and may be capable of regenerating the tumor. Therefore, targeting these predicted lurker cells in combination with androgen-deprivation therapy would likely prevent or delay the onset of CRPC. The goals of this proposal are to provide functional evidence for intermediate luminal progenitor cells as the pre-existing lurker cells in primary prostate tumors, to evaluate potential therapeutic targets in intermediate luminal progenitor cells, and to define candidate biomarkers in intermediate luminal progenitor cells that can predict prognosis and response to hormonal therapy.