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Comprehensive Study of Acute Effects and Recovery After Concussion

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Technical Report,30 Sep 2014,29 Sep 2015

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Medical College of Wisconsin Milwaukee United States

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With the goal of conducting the most comprehensive study of mTBI to date, we hypothesize that there will be a significant correlation between biomechanical, clinical, neurobiological, and neuroradiological markers of mTBI, which will more fully inform a neurobiopsychosocial model of mTBI. With the goal of baseline testing 900 athletes and enrolling 50 injured athletes and 50 contact and 50 non-contact controls over the course of 3 years, the project is progressing on schedule. We baseline tested 545 football athletes from July 13, 2015 to Aug 21, 2015. We enrolled 12 injured athletes and 5 contact controls within the reporting period of performance ending on September 29 a total of 25 injured athletes and 15 controls enrolled by date of submission on October 29, with injury and control accrual ongoing during the current football season. All groups are undergoing follow up evaluations within 6 hours of injury, 48 hours after injury, and 8, 15, and 45 days after injury. These evaluations include advanced brain neuroimaging, blood biospecimen collection, and clinical testing measures assessing balance, neurocognition, symptoms, and psychological health. These evaluations will also be correlated with data from the Head Impact Telemetry system HITS that athletes are wearing throughout the season. Data analysis preparations are underway with subject matter experts developing advanced database platforms and analysis techniques. Submission to FITBIR is also underway with a full time staff member devoted to creating appropriate UDEs, merging existing CDEs for our initial submission, and working directly with FITBIR staff. Ongoing collaboration with co-investigators and our project partners has guided us to a successful launch of this comprehensive study, which will lead to advancing the science of mTBI and improving clinical care in military, sports, and civilian populations.

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