Molecular Epidemiology Investigation of Obesity and Lethal Prostate Cancer
Technical Report,01 Sep 2014,31 Aug 2015
Harvard T. H. Chan School of Public Health Boston United States
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The major objective of the PCRP postdoctoral training award was to provide training and opportunities for the principal investigator PI to further her development as an independent prostate cancer researcher in the field of molecular epidemiology. During the award period the PI performed research incorporating tissue-level biomarker data into epidemiologic studies of prostate cancer progression to investigate the relationship between obesity, the tumor microenvironment, and lethal prostate cancer. Using whole transcriptome gene expression profiling data, she identified a chromatin gene signature that is enriched in the tumor tissue of overweight and obese prostate cancer patients. Furthermore, this chromatin signature was associated with poor prognosis. Upon further validation, these findings support an epigenetic link between obesity and prostate cancer survival. The support of the award has provided many opportunities to enhance the professional development of the PI. The coursework and research activities accomplished over the past year have strengthened her research skills. The PI has presented her research at a number of meetings and conferences throughout the year and has recently submitted a manuscript of the findings from this award. During this period she has developed new collaborations that have led to exciting new research opportunities.