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Molecular Signatures of Chronic Pain Subtypes

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Technical Report,13 Dec 2012,12 Dec 2013

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Duke University Durham United States

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This project continues to be a biomarker discovery program focusing on the causes of persistent pain after traumatic amputation in the combat setting. In the third year we have 1 maintained the necessary regulatory approval at WRNMMC and Duke University. We have 1 obtained and maintained documents for approval by MRMC 2 completed patient enrollment at 124 patients 3 maintained our interactive, secure web based data collection system 4 populated our biorepository at Duke with bioresource collected from 124 patients enrolled at WRNMMC 5 conducted further on-site visits and investigator meetings at WRNMMC 6 Received all data from whole exome sequencing, gene expression, DNA methylation, miRNA, proteomic and metabolomic analysis of the 79 patient VIPER discovery cohort. We have also submitted one more paper for publication and presented two posters at pain medicine meetings. We have identified multiples pathways with biomarker and therapeutic analgesic relevance and received funding from the CDMRP Neurosensory FY 13 award to further study these pathways.

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