Defining the Pathophysiological Role of Tau in Experimental TBI
Technical Report,30 Sep 2014,29 Sep 2015
University of Pennsylvania Philadelphia
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After traumatic brain injury TBI, the human brain sometimes develops tau pathology partly resembling the hallmark neuropathological features of the tauopathy of Alzheimers disease AD. Although tau has been strongly linked to the pathogenesis of AD, its involvement in the pathophysiology of TBI and its influence on brain structural and functional outcomes are unclear. Here we are critically evaluating three hypotheses i tau exacerbates the neuronal damage and cognitive dysfunction after single and repetitive TBI in the acute and chronic post-injury periods ii TBI promotes the severity and spread of tau pathology to contribute to development of a chronic neurodegenerative disorder and iii novel biomarkers for neurodegeneration are non-invasive blood measures of brain damage and dysfunction valuable for the diagnosis, prognosis, and theragnosis of TBI-triggered brain damage and chronic neurodegenerative disease.