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Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans

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Technical Report,30 Sep 2014,29 Sep 2015

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Northern California Institute for Research and Education San Francisco

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The goal of this project is to define the biomarker profile of TBI-associated CI in veterans and compare it to that of veterans with AD and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from AD and normal aging. Specifically, we hypothesize that 1 patients with TBI associated CI will have higher phospho-tautotal tau ratio than controls who have not had a TBI, and that 2 TBI-associated CI will be associated with elevations in inflammatory markers compared to controls and 3 a decrease in b-amyloid measures compared to controls but not as low as in the setting of AD. We currently have data collection ongoing at both sites. As of 30-SEP-2015, data from 31 participants with TBI and 30 controls has been collected. Once data collection is complete, we will examine the biomarker profile of the groups. This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.

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