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A Translational Approach to Validate In Vivo Anti-Tumor Effects of Chloroquine on Breast Cancer Risk

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Technical Report,01 May 2012,30 Apr 2015

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Baylor College of Medicine Houston

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SUBJECT and PURPOSE This translational epidemiologic study conducted online aims to confirm preclinical data on the chemopreventive potential of chloroquine aminoquinoline, a well-characterized anti-malarial drug. BACKGROUND Exposure to chloroquine, an off-patent anti-malarial drug with a 60-year history of use by millions, reduces the incidence of breast cancer in genetically programmed rats by 37. METHODS and SCOPE About 65 of Peace Corps volunteers received chloroquine prophylactically between 1965 and 1990. Therefore, we will collect chloroquine exposure, breast cancer risk, and breast cancer diagnosis data from returned volunteers who served during this period through an online application. We will characterize participants into chloroquine exposed and unexposed groups, based on country of service and self-reported exposure status. The cost and time efficiencies afforded by this study design will allow the translation of preclinical data on breast cancer chemoprevention into public health and potentially promote the repositioning of a well-characterized and inexpensive drug.

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