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Technologies for Hemostasis and Stabilization of the Acute Traumatic Wound

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Technical Report,26 Sep 2014,25 Sep 2015

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University of Nebraska Omaha,

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The purpose of this research is to develop effective hemostatic devices for two difficult types of hemorrhage 1 traumatic non-compressible also known as truncal hemorrhage and 2 traumatic hemorrhage in the cold coagulopathic subject. The scope of this research will include both military and civilian trauma victims, particularly those suffering from hemorrhagic truncal injury andor coagulopathic hemorrhage. During the fourth year Y4 of this project, we continued to generate stocks of two clotting factors fibrinogen and Factor XIII needed for the development and manufacture of our hemostatic devices. In addition, we improved our prototypes to deliver foaming technology for the treatment of non-compressible hemorrhage. We performed efficacy testing of the dual fibrin sealant-alginate foam technology in our non-compressible model, and we currently are making modifications to both our model system and our foam technology to increase the resultant device utility. We devised an ex vivo adhesion assay to help progress in developing treatments for cold coagulopathic hemorrhage. In addition, we obtained a one year no-cost extension on this award, through 25 Sep 2016. In Y5 we will continue to develop our foam technology for non-compressible hemorrhage, and continue our work on treatments for cold coagulopathic hemorrhage, using both ex vivo tensiometer studies and in vivo procedures with our cold coagulopathic porcine hemorrhage model.

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